ABSTRACT
Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) was identified in December (2019) as the cause of an outbreak of a respiratory sickness and has infected more than 190 million people all over the world. Numerous vaccines have been tested for corona virus (Covid-19) therapy such as Hydoxychloroquine, Ribavirin, sofosbuvir, tenofuvir and remdisivir. Hydroxychloroquine (HCQ), which is used in the treatment of malaria or treat infection, has recently been demonstrated for use in COVID-19 as an emergency therapy. The chemical substance HCQ is manufactured by rearranging the molecular structure of Ethylene oxide produced by human products, such as waxy maize starch. In medical science chemical properties, physical properties, pharmaceutical properties and biological properties of medicines are essential for designing of the drugs. These properties can be identified by topological indices. In this paper, we compute the temperature based topological indices of hydroxychoroquine HCQ-HES, and the discoveries will be beneficial in the development of novel drugs and vaccines in order to avoid and operation of corona virus (COVID-19). [ABSTRACT FROM AUTHOR] Copyright of Polycyclic Aromatic Compounds is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
ABSTRACT
Subacute thyroiditis (SAT) is an uncommon, granulomatous, inflammatory thyroid disorder. It usually presents with anterior neck and/or jaw pain, diffusely tender goiter, fever, fatigue, myalgia, and anorexia. Most patients with SAT initially develop symptoms and signs of hyperthyroidism which usually subsides within a few weeks with or without going through a transient phase of hypothyroidism. SAT is usually associated with a viral infection of the upper respiratory tract. We report a case of SAT in a 30-year-old male with a recent COVID-19 infection. The patient presented with a three days history of painful anterior neck mass and palpitations. He was diagnosed with COVID-19 16 days before presentation. His infection was mild and did not need any treatment apart from as-needed paracetamol. The patient was found to have a clinical, laboratory, and imaging findings consistent with SAT. The patient was prescribed ibuprofen, prednisone, and propranolol. The patient showed significant clinical and biochemical improvement on follow-up visits, achieving a euthyroid state within several weeks. Like many other respiratory viral illnesses, COVID-19 also seems to be associated with SAT. Other endocrinological sequelae have also been reported. While reviewing patients suffering from COVID-19 infection, these possibilities should be kept in mind.